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What is Iressa (gefitinib) ?
Iressa (gefitinib) is a cancer medication that interferes with the growth and spread of cancer cells in the body. It is used to treat non-small cell lung cancer.
Iressa is sometimes used to treat cancer that has spread to other parts of the body.
Iressa is the first selective inhibitor of epidermal growth factor receptor’s (EGFR) tyrosine kinase domain. Thus gefitinib is an EGFR inhibitor. The target protein (EGFR) is a member of a family of receptors (ErbB) which includes Her1(EGFR), Her2(erb-B2), Her3(erb-B3) and Her4 (Erb-B4). EGFR is overexpressed in the cells of certain types of human carcinomas – for example in lung and breast cancers. This leads to inappropriate activation of the anti-apoptotic Ras signalling cascade, eventually leading to uncontrolled cell proliferation. Research on gefitinib-sensitive non-small cell lung cancers has shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways. These mutations tend to confer increased sensitivity to tyrosine kinase inhibitors such as gefitinib and erlotinib. Of the types of non-small cell lung cancer histologies, adenocarcinoma is the type that most often harbors these mutations. These mutations are more commonly seen in Asians, women, and non-smokers (who also tend to more often have adenocarcinoma).
Gefitinib inhibits EGFR tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme. Thus the function of the EGFR tyrosine kinase in activating the anti-apoptotic Ras signal transduction cascade is inhibited, and malignant cells are inhibited.
Some side effects of Iressa
Call your doctor at once if you experience any of the following side effect:
- severe or ongoing diarrhea;
- sudden chest pain or discomfort, new or worsening cough with fever, trouble breathing;
- blurred vision, watery eyes, eye pain or redness, eyes being more sensitive to light;
- liver problems – nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- signs of stomach bleeding – severe stomach pain, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or
- severe skin reaction – fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common Iressa side effects may include:
- dry skin; or
- itching or skin rash.
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